On the Stability Crossing Boundaries of Some Delay Systems Modeling Immune Dynamics in Leukemia

نویسندگان

  • Silviu-Iulian Niculescu
  • Peter S. Kim
  • Keqin Gu
  • Doron Levy
چکیده

This paper focuses on the characterization of delay effects on the asymptotic stability of some continuoustime delay systems encountered in modeling the posttransplantation dynamics of the immune response to chronic myelogenous leukemia. More explicitly, we shall discuss the stability of the crossing boundaries of the corresponding linearized models in the delay-parameter space. Weak, and strong cell interactions are discussed, and analytic characterizations are proposed. An illustrative example completes the presentation. Keywords— Delay; asymptotic stability; switch; reversal; crossing curves; quasipolynomial.

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تاریخ انتشار 2006